Trimethoprim-sulphamethoxazole in gonorrhoea. A comparison with privampicillin combined with probenecid.

Treatment of gonorrhoea with trimethoprim-sulphamethoxazole and probenecid plus procaine penicillin in Rwanda.

Treatment of acute gonococcal urethritis in men with simultaneous infection with Chlamydia trachomatis.

Each of 201 men with symptoms and signs of acute urethritis was randomly assigned to one of two treatment regimens: ampicillin (2g) plus probenecid (1g), or sulphamethoxazole-trimethoprim (SMX-TMP) (sulphamethoxazole 1600 mg plus trimethoprim 320 mg) four tablets twice daily for two days. Before treatment Neisseria gonorrhoeae was isolated from 162 patients, while coexistent Chlamydia trachomat...

Sulphamethoxazole combined with 2-4-diamino-pyrimidines in the treatment of gonorrhoea.

THE synergistic action of the combination ofsulphonamides and 2-4-diamino-pyrimidine compounds against the gonococcus has been demonstrated clinically by Csonka and Knight (1967). It was decided to reassess the clinical efficacy of the combination of trimethoprim with sulphamethoxazole* in gonorrhoea, to examine its mode of action, and to compare the effect of a combination of another pyrimidin...

Short-term treatment of gonorrhoea with intramuscular and oral forms of trimethoprim-sulphamethoxazole.

Fifty-nine male patients and 41 female patients with uncomplicated gonorrhoea were treated with an intramuscular dose of 1600 mg sulphamethoxazole plus 320 mg trimethoprim followed by an oral dose of 2400 mg sulphamethoxazole plus 480 mg trimethoprim 12 hours later. Forty-nine out of 52 male patients and 37 out of 38 female patients who were re-examined were cured. One of the men probably had a...

Simulataneous Analysis of Trimethoprim and Sulphamethoxazole Drug Combinations in Dosage Forms by High Performance Liquid Chromatography

A sensitive high performance liquid chromathography (HPLC) analytical procedure was developed for the quantitive determination of trimethoprim (TM* and sulphamethoxazole (SM) in commercial dosage forms. C18 analytical column (stainless steel, 25 cm * 4.6 mm i.d.) was packed with 5-*m particles of the reversed phase material and used for assays. Mobile phase containing 0.025 M sodium phosphate...